JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SEALOCK, R. R.
Right arrow Articles by DU VIGNEAUD, V.
Right arrow Search for Related Content
PubMed
Right arrow Articles by SEALOCK, R. R.
Right arrow Articles by DU VIGNEAUD, V.
Journal of Pharmacology And Experimental Therapeutics, Vol. 54, Issue 4, 433-447, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE REDUCTION OF PITRESSIN AND PITOCIN WITH CYSTEINE

ROBERT RIDGELY SEALOCK 1 and VINCENT DU VIGNEAUD 1

1 From the Department of Biochemistry, School of Medicine, George Washington University, Washington

The physiological activity of the pressor and oxytocic principles of the posterior pituitary gland is not appreciably altered when treated with cysteine, in slightly alkaline solution, in contrast to the behavior of insulin. Reoxidation likewise did not affect the activity.

Inactivation resulted with benzylation or methylation of the reduced pitocin and pitressin whereas no effect on the activity of the reduced material resulted by such treatment. This demonstrated, furthermore, that both pitressin and pitocin were actually reduced by the cysteine in the above experiments.

The results obtained offer almost conclusive proof that these active principles contain sulfur in the disulfide form.

In addition the evidence obtained indicates the necessity of the presence of a sulfhydryl or a potential sulfhydryl group to the activity of both pitressin and pitocin.

Submitted on May 28, 1935




This article has been cited by other articles:


Home page
 ScienceHome page
C. RESSLER
Inactivations of Oxytocin Suggesting Peptide Denaturation
Science, November 21, 1958; 128(3334): 1281 - 1282.
[PDF]

Home page
 ScienceHome page
V. du Vigneaud
Trail of Sulfur Research: from Insulin to Oxytocin
Science, June 1, 1956; 123(3205): 967 - 974.
[PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.