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Journal of Pharmacology And Experimental Therapeutics, Vol. 54, Issue 4, 426-432, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF VARIOUS ANESTHETICS ON SALIVARY SECRETION

BENJAMIN H. ROBBINS 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

1. It has been shown that regardless of the mode of administering ether, by cone, by rectum or by intravenous injection, it increases or stimulates salivary secretion during induction and recovery, if the vapors are permitted to pass over the upper respiratory or buccal mucosa.

2. All of the anesthetics cause a cessation of salivary secretion during anesthesia by depressing the secretory center.

3. Using the change in rate of salivary secretion as an index of the irritant action of anesthetics to the upper respiratory mucosa one may say that ether and chloroform are about equally irritant, cyclopropane slightly less irritating, and that ethylene and nitrous oxide are not irritating.

Submitted on May 27, 1935




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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.