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Journal of Pharmacology And Experimental Therapeutics, Vol. 54, Issue 4, 371-377, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

ALCOHOL INJECTED INTRAVENOUSLY: RATE OF DISAPPEARANCE FROM THE BLOOD STREAM IN MAN

HENRY W. NEWMAN 1 and WINDSOR C. CUTTING 1

1 Division of Neuropsychiatry and Department of Medicine, Stanford University School of Medicine

The curve of blood alcohol plotted against time, after a single dose of from 0.5 to 1.5 cc. per kilogram administered intravenously to man, is a straight line, the rate of decline being independent of the height of the blood alcohol, but varying considerably from individual to individual.

The amount of alcohol per unit time required to maintain the blood alcohol of an individual at a given concentration is constant and independent of the height of the blood alcohol, at least within the limits of this investigation, 15 to 94 mgm. per 100 cc. The average for our subjects was 0.174 cc. per kilogram per hour, closely approximating the value of 0.185 cc. obtained by Mellanby in dogs.

Submitted on April 15, 1935






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.