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Journal of Pharmacology And Experimental Therapeutics, Vol. 54, Issue 3, 346-351, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

THE RATIO OF THE TOXICITY OF ACETANILID TO ITS ANTIPYRETIC ACTIVITY IN RATS

PAUL K. SMITH 1 and W. E. HAMBOURGER 1

1 From the Department of Pharmacology and Toxicology, Yale University

In rats fevered by yeast injections, a dose of 12.5 mgm. per kilogram of acetanilid produces an average fall in temperature of 0.6°C., while smaller doses are without significant effect and larger doses produced greater effects. Twelve and one-half milligrams per kilogram has been taken to the minimal therapeutic dose for rats.

In normal animals, 50 mgm. per kilogram of acetanilid produces a significant decrease in temperature, similar to the fall produced in fevered animals by 12.5 mgm. per kilogram. The lowering of the temperature of the normal animal may be considered an early undesirable effect.

The dose fatal to 50 per cent of the rats is 800 mgm. per kilogram.

A therapeutic ratio of 64:1 for the antipyretic effect of acetanilid in rats has been obtained.

Submitted on April 17, 1935






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.