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Journal of Pharmacology And Experimental Therapeutics, Vol. 54, Issue 1, 84-86, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

REMARKS ON THE DISTRIBUTION OF BARBITURATES IN THE BRAIN

THEODORE KOPPANYI 1 and JAMES M. DILLE 1

1 From the Department of Pharmacology and Materia Medica, Georgetown University School of Medicine

The distribution of barbital in the different parts of the central nervous system is the same after large, i.e. anesthetic (225 to 600 mgm. per kilogram) and after small, i.e., hypnotic doses (50 to 100 mgm. per kilogram).

Keeser and Keeser's claim of specific distribution of barbital and its accumulation in the so-called sleep centers after the administration of small hypnotic doses could not be confirmed.

Submitted on February 27, 1935






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.