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Journal of Pharmacology And Experimental Therapeutics, Vol. 54, Issue 1, 77-83, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

SODIUM N-METHYL-CYCLOHEXENYL-METHYL-BARBITURIC ACID (EVIPAL): HYPNOSIS, ANESTHESIA AND TOXICITY

A. H. MALONEY 1 and R. HERTZ 1

1 Department of Pharmacology, Howard University School of Medicine, Washington, D. C.

A study is made of the hypnotic and anesthetic action and the toxicity of evipal in rats and rabbits.

1. The optimal hypnotic dose is 50 mgm. per kilogram for the rat.

2. The optimal anesthetic dose is 100 mgm. per kilogram for the rat and 70 mgm. per kilogram for the rabbit.

3. The m.l.d. for the rat is 280 mgm. per kilogram; for the rabbit the exact figure was not determined.

4. This compound has a high coefficient of effectiveness. The toxic-anesthetic-hypnotic ratios in the rat being 100:36:18.

5. Because of the uniformity of results the intraperitoneal method of administration was employed.

6. The response of the animals to evipal intoxication is described.

Submitted on February 27, 1935






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.