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Journal of Pharmacology And Experimental Therapeutics, Vol. 54, Issue 1, 25-33, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

THE RESPIRATORY EFFECTS OF MORPHINE, CODEINE AND RELATED SUBSTANCES IV. THE EFFECT OF agr-MONOACETYLMORPHINE, MONOACETYLDIHYDROMORPHINE, DIACETYLMORPHINE (HEROIN) AND DIACETYLDIHYDROMORPHINE ON THE RESPIRATORY ACTIVITY OF THE RABBIT

CHARLES I. WRIGHT 1 and FLEMING A. BARBOUR 1

1 From the Laboratory of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

agr-Monoacetylmorphine, diacetylmorphine and two hydrogenated acetyl derivatives have been compared as to their effectiveness in decreasing the rabbits' respiratory rate, minute volume and sensitivity to stimulation by carbon dioxide. Observations were also made of the effect of the drugs on rectal temperature and heart rate.

The least doses (milligram per kilogram) causing a decrease in respiratory activity are (a) agr-monoacetylmorphine, 0.03, (b) monoacetyldihydromorphine, 0.2 to 0.25, (c) diacetylmorphine, 0.02 to 0.04, (d) diacetyldihydromorphine, 0.2 to 0.25.

Submitted on February 14, 1935






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.