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Journal of Pharmacology And Experimental Therapeutics, Vol. 53, Issue 4, 465-473, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF CAFFEINE AND THEOBROMINE UPON DIGITALIS TOXICITY: AN EXPERIMENTAL STUDY

H. B. HAAG 1 and J. D. WOODLEY 1

1 From Department of Pharmacology, Medical College of Virginia, Richmond

A brief resumé of the literature relative to the changes in toxicity of digitalis bodies under the influence of xanthine derivatives shows much divergence of opinion.

Ouabain, strophanthin, digitoxin and three tinctures of digitalis have been assayed according to the technic of Hatcher and Brody. The results so obtained have been compared to values similarly determined, but upon cats receiving varying amounts of caffeine or theobromine subcutaneously and intravenously.

The toxicity of ouabain remained practically unaffected in animals receiving from 10 to 50 mgm. caffeine subcutaneously, and 40 mgm. intravenously, though the results suggested that the smaller doses of caffeine might be slightly protective, while the larger ones slightly synergistic as regards the toxic effect of ouabain. Likewise, the potency of strophanthin was unaltered in cats receiving 32 mgm. caffeine intravenously. Theobromine in amounts of from 32 to 38 mgm. did not change the minimum lethal dose of either of these two digitaloids.

When caffeine was administered in amounts of from 2 to 10 mgm. subcutaneously, it did not influence the toxicity of two tinctures of digitalis. In amounts of 20 mgm., caffeine slightly increased the physiological potency of one tincture; that of the other remained unchanged. Larger doses of caffeine up to 50 mgm. subcutaneously and by vein consistently seem to slightly increase the toxicity of all the preparations of digitalis studied. Similar results were obtained with theobromine.

The results indicate that in the amounts ordinarily employed clinically caffeine and theobromine probably do not influence the toxicity of ouabain, strophanthin or digitalis preparations to any appreciable extent.

Submitted on February 4, 1935




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 Arch Intern MedHome page
J. TRAVELL, H. GOLD, and W. MODELL
EFFECT OF EXPERIMENTAL CARDIAC INFARCTION ON RESPONSE TO DIGITALIS
Arch Intern Med, February 1, 1938; 61(2): 184 - 197.
[Abstract] [PDF]


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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.