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Journal of Pharmacology And Experimental Therapeutics, Vol. 53, Issue 4, 454-464, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF LOCAL ANAESTHETICS ON THE RESPIRATORY APPARATUS

E. FALKNER HILL 1 and A. D. MACDONALD 1

1 From the Department of Pharmacology, University of Manchester

The mechanism by which the local anaesthetics may produce respiratory failure varies with the route by which they are exhibited. Evidence is given for a depression of the respiratory centre as the main action when the drug is absorbed into the circulation or introduced into the cisterna magna or fourth ventricle. When the drug is introduced by lumbar puncture the greater danger lies in an extension of its action to the nerve roots of the respiratory muscles, and especially to the phrenic roots.

Submitted on December 6, 1934






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.