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Journal of Pharmacology And Experimental Therapeutics, Vol. 53, Issue 4, 401-417, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

ACETANILID POISONING A CLINICAL AND EXPERIMENTAL STUDY

SHELDON PAYNE 1

1 From the Departments of Biochemistry and of Medicine, Duke University School of Medicine and Hospital, Durham, North Carolina

1. The clinical features of acute and chronic acetanilid poisoning have been reviewed briefly.

2. In experiments on two dogs the first effect of daily acetanilid ingestion was an anemia. Following prolonged administration the animals gained tolerance. After ingestion of acetanilid there was a transient methemoglobinemia and increase in blood phenol. During methemoglobinemia oxygen capacity falls and symptoms of anoxemia may result. No cardiac damage was demonstrable by electrocardiograms. Acetanilid is habit forming.

Submitted on January 2, 1935






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.