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Journal of Pharmacology And Experimental Therapeutics, Vol. 53, Issue 2, 156-168, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

FFFECT OF MORPHINE ON THE OXYGEN CONSUMPTION OF BRAIN TISSUE IN THE RAT

E. G. GROSS 1 and I. H. PIERCE 1

1 From the Department of Pharmacology, State University of Iowa, Iowa City

1. Morphine added to hashed brain tissue of the rat decreases the oxygen consumption due to added glucose.

2. Brain from non-tolerant animals killed one hour after a subcutaneous injection of morphine show an increased oxygen consumption over the normal for a period of four to five hours, due to the increased glucose.

3. Brain from morphine-tolerant rats exhibits the same metabolic rate as that from normal animals.

4. Subcutaneous injection of morphine into non-tolerant animals produces no change in the metabolic rate of kidney and testis.

Submitted on November 16, 1934






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.