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Journal of Pharmacology And Experimental Therapeutics, Vol. 53, Issue 2, 142-155, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

THE TENSION OUTPUT OF CAFFEINIZED MUSCLES

G. SASLOW 1 and E. C. WEBSTER 1

1 From Washington Square College, New York University and Marine Biological Laboratory, Woods Hole, Massachusetts

The action of caffeine on muscle at concentrations below contracture level has been investigated with a rigidly controlled method involving the measurement of the total work of the muscle on a tension lever.

Opposite actions of the drug, beneficial at low concentrations and injurious at high, were not observed. The drug, in concentrations at which it was effective, invariably reduced the tension output of the frog gastrocnemius.

The depressant effect could be abolished completely by washing with Ringer, provided that the caffeine concentration employed was 0.05 per cent or lower.

Submitted on November 12, 1934






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.