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Journal of Pharmacology And Experimental Therapeutics, Vol. 53, Issue 1, 90-104, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

A COMPARATIVE STUDY OF CYCLOPROPANE AND ETHYLENE WITH REFERENCE TO BODY SATURATION AND DESATURATION

M. H. SEEVERS 1, S. F. DE FAZIO 1, and S. M. EVANS 1

1 From the Department of Pharmacology of the University of Wisconsin

Evidence is presented to show that cyclopropane does not isomerize to propylene in the body.

The gas depot method for the study of tissue gases appears to be applicable to the investigation of gaseous anesthetics.

Curves based upon tissue gas analysis showing the comparative rates of absorption and elimination of cyclopropane and ethylene from the splanchnic and skin regions of the rabbit and dog, are presented.

Both regions saturate and desaturate with cyclopropane in half the time required for ethylene.

The splanchnic region reaches saturation twice as rapidly as the skin. This ratio holds for both gases in both animals and is interpreted to mean that the minute volume of blood flow is twice as great in the splanchnic area as in the subcutaneous tissues.

Rabbit tissues reach saturation with both gases about 50 per cent more rapidly than those of the dog.

The tension of carbon dioxide in tissues is higher during cyclopropane than during ethylene anesthesia.

Submitted on October 20, 1934






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.