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Journal of Pharmacology And Experimental Therapeutics, Vol. 53, Issue 1, 34-45, 1935
Copyright © 1935 by American Society for Pharmacology and Experimental Therapeutics

THE RESPIRATORY EFFECTS OF MORPHINE, CODEINE AND RELATED SUBSTANCES III. THE EFFECT OF MORPHINE, DIHYDROMORPHINE, DIHYDROMORPHINONE (DILAUDID) AND DIHYDROCODEINONE (DICODID) ON THE RESPIRATORY ACTIVITY OF THE RABBIT

CHARLES I. WRIGHT 1 and FLEMING A. BARBOUR 1

1 From the Laboratory of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

Morphine, dihydromorphine, dilaudid and dicodid have been compared as to their effectiveness in decreasing the rabbit's respiratory rate, minute volume and sensitivity to stimulation by carbon dioxide. Observations were also made on the rectal temperature and heart rate as affected by these drugs.

The minimum doses (milligram per kilogram of base) required to decrease the respiratory activity are (a) morphine 0.32, (b) dihydromorphine 0.22 to 0.27, (c) dilaudid 0.027 to 0.035, (d) dicodid 0.21 to 0.30. Hydrogenation of morphine has very little if any effect on its action on respiration. The presence of a ketonic oxygen on the 6-carbon (dilaudid and dicodid) increases the effectiveness of the drug tenfold.

Submitted on September 19, 1934






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Copyright © 1935 by the American Society for Pharmacology and Experimental Therapeutics.