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Journal of Pharmacology And Experimental Therapeutics, Vol. 52, Issue 4, 383-389, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE DENERVATED KIDNEY II. THE ACTION OF SODIUM SALICYLATE ON THE URIC ACID, ALLANTOIN, SODIUM CHLORIDE AND TOTAL NITROGEN EXCRETION IN DOGS

M. G. GRAY 1 and G. P. GRABFIELD 1

1 From the Laboratory of Pharmacology, Harvard Medical School

1. The effect of sodium salicylate on the urinary uric acid and allantoin excretion was studied in three dogs on a constant diet before and after renal denervation.

2. The excretion of allantoin was on a lower level postoperatively but showed a typical rise during salicylate medication.

3. The usual uricosuric effect of the salicylates was reversed after section of the renal nerves. Successive studies showed a decrease in this effect, probably associated with regeneration of nerve fibres.

4. A slight decrease in the extent of the total nitrogen rise was seen after operation.

5. There is a reversal of the relationship of chloride to water excretion during salicylate medication which is not altered by denervation.

6. The uricosuric action of the salicylates is apparently dependent upon the renal nerves and is in this respect like that of cinchophen.

Submitted on August 13, 1934






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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.