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Journal of Pharmacology And Experimental Therapeutics, Vol. 52, Issue 3, 235-245, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

THE RÔLE OF ADRENALINE IN THE PRODUCTION OF VENTRICULAR RHYTHMS AND THEIR SUPPRESSION BY ACETYL-beta-METHYLCHOLINE CHLORIDE

H. E. HOFF 1 and L. H. NAHUM 1

1 From the Laboratory of Physiology, Yale University School of Medicine

1. Ventricular rhythms arise when the rhythmicity of some ventricular focus exceeds that of the pacemaker.

2. In normal animals intravenous injections of adrenaline produce ventricular rhythms by increasing the rhythmicity of the ventricles while at the same time the rate of the pacemaker is decreased by the depressor reflex.

3. Benzol, chloroform and probably other factors, sensitize the ventricular myocardium to the adrenaline in the body, and in this way so increase the ventricular rhythmicity that ventricular rhythms appear.

4. These ventricular rhythms are readily abolished by acetylcholine (acetyl-beta-methylcholine chloride) in appropriate doses.

5. Evidence is presented that acetylcholine not only depresses the rhythmicity of the pacemaker and auricle where vagal endings are known to exist, but also that of the ventricular myocardium.

Submitted on May 23, 1934




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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.