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Journal of Pharmacology And Experimental Therapeutics, Vol. 52, Issue 2, 223-230, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON BARBITURATES X. ACUTE BARBITAL POISONING IN DEHYDRATION AND DIURESIS

THEODORE KOPPANYI 1, WILLIAM S. MURPHY 1, and STEPHEN KROP 1

1 From the Department of Pharmacology and Materia Medica, Georgetown University, School of Medicine, Washington, D. C.

The treatment of acute barbital poisoning by simple diuretic measures (sodium sulphate, glucose, physiological salt solution or calcium chloride) does not hasten the excretion of barbital. A mere dilution of the urine by glucose or saline diuretics does not lead to an increased elimination of barbital. Intravenous administration of ammonium chloride solutions promotes the excretion of barbital in the urine, but does not significantly increase the elimination of barbiturates other than barbital. Ammonium chloride medication, however, did not significantly hasten the recovery from barbital narcosis.

Submitted on June 25, 1934






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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.