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Journal of Pharmacology And Experimental Therapeutics, Vol. 52, Issue 2, 216-222, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

THE RELATIVE ANESTHETIC EFFECTS OF SOME ALIPHATIC UREAS

EDWIN J. DEBEER 1, JOHANNES S. BUCK 1, and AXEL M. HJORT 1

1 From the Burroughs Wellcome and Company, U. S. A., Experimental Research Laboratories, Tuckahoe, New York

1. Two homologous series of alkyl ureas, the n-alkyl and iso-alkyl homologs, have been tested on mice for the presence of anesthetic properties.

2. All of these ureas, with the exception of the n-heptyl compound, which was too insoluble, were found to have anesthetic activity in varying degree.

3. The anesthetic effects and toxicities increased with the molecular weight. The increase of the anesthetic effects was more rapid than that of the toxicities, thus the compounds of 4, 5 and 6 carbon atoms had the more favorable physiological indices.

Submitted on July 24, 1934






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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.