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Journal of Pharmacology And Experimental Therapeutics, Vol. 52, Issue 1, 91-100, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON BARBITURATES VII. EXPERIMENTAL ANALYSIS OF BARBITAL ACTION

THEODORE KOPPANYI 1 and JAMES M. DILLE 1

1 From the Department of Pharmacology and Materia Medica, Georgetown University School of Medicine

Rabbits receiving daily doses of barbital show a lag in excretion. After the administration of 50 or 100 mgm. per kilogram, there is no accumulation of effects. Albino rabbits are more susceptible to toxic effects of barbital. Cats although showing an optimum excretion of barbital, exhibit accumulation of effects terminating in depression, coma, and respiratory failure. An analysis of these results indicates that rabbits acquire the ability to oxidize barbital, whereas in cats and dogs the depression after maximum excretion of barbital is due to retention of the drug by the brain cells.

Submitted on June 25, 1934






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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.