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Journal of Pharmacology And Experimental Therapeutics, Vol. 52, Issue 1, 87-90, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON BARBITURATES VI. THE ELIMINATION OF ISOAMYL ETHYL BARBITURIC ACID ("AMYTAL") AND N-BUTYL ETHYL BARBITURIC ACID ("NEONAL")

THEODORE KOPPANYI 1 and STEPHEN KROP 1

1 From the Department of Pharmacology and Materia Medica, Georgetown University School of Medicine

Neonal and amytal are not completely destroyed in the body but are excreted in the urine to the extent of about 8 per cent of the administered dose. Amytal may be recovered in human urines and thus the quantitative barbiturate test may be utilized in the diagnosis of amytal and also of neonal poisoning. Iso-butyl-allyl barbituric acid ("sandoptal") and phenylbutyl barbituric acid are excreted in the urine to the extent of about 1 per cent only.

Submitted on June 25, 1934






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