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Journal of Pharmacology And Experimental Therapeutics, Vol. 52, Issue 1, 70-77, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON BARBITURATES IV. EFFECT OF BARBITURATES IN EXPERIMENTAL NEPHROSIS

WILLIAM S. MURPHY 1 and THEODORE KOPPANYI 1

1 From the Department of Pharmacology and Materia Medica, Georgetown University, School of Medicine, Washington, D. C.

Severe nephrosis was produced by tartaric acid, potassium chromate and uranium acetate. These nephrotic animals showed a decreased elimination and a low concentration of barbital in the urine and a retention of the drug in the blood and tissues. When barbital was administered to severely nephrotic animals in anesthetic doses these animals failed to recover from the anesthesia and eventually died in barbital or uremic coma. Nephrotic animals recovered from anesthesia produced by n-butyl ethyl barbituric acid ("neonal"), iso-butyl allyl barbituric acid ("sandoptal"), sodium ethyl (1-methylbutyl) barbiturate ("nembutal") and sec. butyl beta bromallyl barbituric acid ("pernoston").

The therapeutic and possible diagnostic significance of these findings is discussed.

Submitted on June 25, 1934




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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.