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Journal of Pharmacology And Experimental Therapeutics, Vol. 51, Issue 4, 421-429, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF TISSUE EXTRACT AND OTHER VASCULAR DEPRESSOR SUBSTANCES ON ISOLATED INTESTINES

JEAN D. CRAVEN 1 and FOREST D. McCREA 1

1 From the Departments of Pediatrics, Physiology and Pharmacology, Duke University, Durham, North Carolina

1. Tissue extract produced a contraction of all segments of the intestine of guinea pigs, but did not contract the intestine of rats or rabbits.

2. Tissue extract caused contraction only in alkaline solutions, relaxation occurring when the reaction of the solutions was slightly acid.

3. The action of tissue extract on the guinea pig, rat, and rabbit intestines was similar to that of histamine.

4. The active principle of tissue extract is not acetylcholine or methylguanidine.

5. Permutit absorbed the active principle of tissue extract as well as that of histamine.

Submitted on May 4, 1934






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