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Journal of Pharmacology And Experimental Therapeutics, Vol. 51, Issue 1, 97-111, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

THE RÔLE OF ACETYLCHOLINE IN BLADDER CONTRACTILE MECHANISMS AND IN PARASYMPATHETIC GANGLIA

V. E. HENDERSON 1 and M. H. ROEPKE 1

1 Department of Pharmacology, University of Toronto

1. We believe that our experiments have shown that (a) there is both a contractile and tonus mechanism in the bladder; (b) that the stimulation of tonus nerve fibres is mediated by the production of acetylcholine in the bladder and (c) that the stimulation of the contractile nerve fibres is not mediated by acetylcholine but in some other way.

2. Atropine depresses the tonus mechanism, but not the contractile one.

3. Our experiments suggest that acetylcholine is the mediating substance between pre- and postganglionic fibres in parasympathetic nerve ganglia, as has been shown with sympathetic ganglia.

4. Atropine does not affect the action of the mediating acetylcholine in autonomic ganglia.

Submitted on March 1, 1934




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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.