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Journal of Pharmacology And Experimental Therapeutics, Vol. 51, Issue 1, 18-22, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF POSTERIOR PITUITARY PREPARATIONS ON THE BLOOD FLOW OF THE NORMAL INTACT DOG

E. M. K. GEILING 1, J. F. HERRICK 1, and HIRAM E. ESSEX 1

1 The Department of Pharmacology and Experimental Therapeutics, Johns Hopkins School of Medicine, Baltimore, Maryland, and Division of Experimental Medicine, The Mayo Clinic, Rochester, Minnesota

The blood flow in the femoral artery, femoral vein, carotid artery, and jugular vein shows a marked decrease following the intravenous injection of the pressor fraction of the posterior lobe of the pituitary gland. This decrease is prolonged and the preinjection level is not attained until about one and a half hours have elapsed. When pitressin is inactivated with alkali, no effect on the blood flow is observed. The oxytocic fraction also has no significant effect.

The pressor fraction produces similar effects on the blood flow in the femoral artery of a sympathectomized and an adrenalectomized dog.

Submitted on January 26, 1934




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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.