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Journal of Pharmacology And Experimental Therapeutics, Vol. 50, Issue 4, 420-424, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

OBSERVATIONS REGARDING THE MECHANISM OF GASTRO-INTESTINAL INHIBITION BY BARBITURIC ACID COMPOUNDS

J. P. QUIGLEY 1 and K. R. PHELPS 1

1 From the Department of Physiology, Western Reserve University, Medical School, Cleveland, Ohio

In a series of otherwise normal animals the stomachs were denervated by sectioning the extrinsic gastric nerves. The intravenous administration of pentobarbital or barbital as sodium salts produced an inhibition of gastric tone and motility in denervated stomachs similar to that noted in the stomach having normal innervation. It appears evident that the members of the barbituric acid series depress the motor activity of smooth muscle by an action on the smooth muscle cells directly or perhaps on the intrinsic nervous tissue.

Submitted on January 17, 1934






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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.