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Journal of Pharmacology And Experimental Therapeutics, Vol. 50, Issue 3, 336-345, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

THE MECHANISM OF SUDDEN DEATH IN EXPERIMENTAL ACUTE BENZOL POISONING

L. H. NAHUM 1 and H. E. HOFF 1

1 From the Laboratory of Physiology, Yale University School of Medicine

1. Ten cats and two monkeys were exposed to benzol vapor in high concentration.

2. In the intact animal such exposure invariably led to the appearance of ventricular extrasystoles and ventricular tachycardia of a pre-fibrillation type. These irregularities appeared during the period of induction or recovery.

3. The removal of the adrenal glands in three animals reduced, but did not abolish, the ventricular extrasystoles, and the removal of both stellate ganglia in four cases was not effective in reducing the frequency of ventricular rhythms.

4. With the adrenal glands and the stellate ganglia both excised, in three experiments, ventricular rhythms no longer appeared. They were immediately produced after the subcutaneous injection of adrenaline. When benzol was not inhaled such doses of adrenaline had only cardio-accelerator effects.

5. During the stage of narcosis respiratory failure occurred and associated with it were progressive anoxemic changes in the electrocardiogram.

Submitted on January 25, 1934




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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.