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Journal of Pharmacology And Experimental Therapeutics, Vol. 50, Issue 3, 328-335, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF SOME COMPOUNDS OF BARBITURIC ACID AND OF URETHRANE

N. RAKIETEN 1, L. H. NAHUM 1, D. DUBOIS 1, E. F. GILDEA 1, and H. E. HIMWICH 1

1 From the Laboratory of Physiology and the Department of Psychiatry and Mental Hygiene, Yale University School of Medicine

Amytal, nembutal, luminal, "Dial-Ciba" and urethane in narcotic doses have a decided effect on the acid-base equilibrium and produce a definite acidosis. The effects of amytal, nembutal and luminal on the blood constituents studied may be grouped together. With the exception of its effect on pH "Dial-Ciba" with its barbituric acid and urethane components has a different action. The effect on CO2 content is the result of both its components while the urethane action predominates on the other blood constituents.

The change in O2 and CO2 content and capacity and blood sugar are given in table 4 together with possible causes for these changes.

Submitted on December 12, 1933






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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.