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1 From the Bermuda Biological Station for Research, Inc. and the Department of Physiology and Pharmacology, Duke University Medical School
1. Acetylcholine, pilocarpine and barium cause sustained contractions of the isolated intestine and stomach of teleost fish whereas histamin and physostigmine are practically without action.
2. Atropin causes immediate relaxation of the intestine contracted by acetylcholine or pilocarpine, but epinephrine causes further contraction which is only rarely followed by relaxation.
3. Epinephrine will cause relaxation in an intestine contracted by mechanical stimuli.
4. Nicotine added after acetylcholine or pilocarpine causes further contraction which is sustained. Even in concentrations of one part in five hundred, it fails to produce relaxation.
5. The calcium ion is necessary for contraction.
Submitted on October 11, 1933
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