THE ACTION OF CERTAIN NUCLEIC ACID DERIVATIVES ON THE CORONARY FLOW IN THE DOG

¹ From the Department of Pathology, Cambridge University

The action of adenosine, muscle and yeast adenylic acids, and cytidylic acid on the coronary flow of the dog's heart has been studied by the Morawitz technique for drainage for the coronary sinus. Following the intravenous administration of any of these substances in doses from 0.5 to 15 mgm. definite increases in coronary flow, which lasted from one to three minutes, invariably occurred, regardless of any simultaneous fall in the mean blood pressure. With the smaller doses, increases in coronary flow were sometimes observed when there was no change in the general blood pressure. The coronary vessels appeared more sensitive to the action of these substances than vessels in other parts of the body. Intramuscular injection of yeast adenylic acid was ineffective.

Of the nucleic acid derivatives investigated yeast adenylic acid produced the greatest increase in coronary flow over the longest period of time. Yeast cytidylic acid was almost as potent.

The anticoagulant value of chlorazol which was studied for goats, rabbits, and cats by Huggett is confirmed for the dog. With adequate quantities, clotting was prevented and no adverse effects could be attributed to the dye.

This article has been cited by other articles:

				D. J. Cheek, J. M. McHugh, J. Blood-Siegfried, J. F. McFetridge, and B. S. Turner A Historical Perspective on the Discovery of Adenyl Purines Biol Res Nurs, April 1, 2000; 1(4): 265 - 275. [Abstract] [PDF]