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Journal of Pharmacology And Experimental Therapeutics, Vol. 50, Issue 1, 93-99, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

TOXICITY OF ALPHA- AND BETA-NICOTINES AND NORNICOTINES AN INQUIRY INTO CHEMOPHARMACODYNAMIC RELATIONSHIPS

DAVID I. MACHT 1 and MARY E. DAVIS 1

1 Pharmacological Research Laboratory, Hynson, Westcott & Dunning, Inc., Baltimore

1. The relative toxicity of alpha- and beta-nicotines and nornicotines was studied on nine different physiological test objects, including animals and plants.

2. The levogyrous nicotine is usually more potent pharmacologically than the dl or racemic variety, but there are some exceptions to this rule in case of certain classes of animals.

3. All the beta compounds were found to be more potent than the alpha compounds of the series.

4. The methyl group attached to the pyrrolidin nucleus of nicotine makes it more toxic for some classes of animals, on the one hand; and less toxic for other classes of animals, on the other hand, than the corresponding nornicotine.

Submitted on July 15, 1933






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