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Journal of Pharmacology And Experimental Therapeutics, Vol. 50, Issue 1, 51-60, 1934
Copyright © 1934 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF PATHOLOGIC STATES ON THE MINIMUM LETHAL DOSE OF PROCAINE INTRACISTERNALLY

FRANK WANG COTUI 1

1 Laboratory of Surgical Research, New York University and Bellevue Medical College, New York City

1. The effect of different pathologic states on the minimum lethal dose of procaine hydrochloride injected into the cisterna magna was studied on dogs.

2. Pneumonia, marked post-operative infection and certain hypotensive states produced by hemorrhage, amyl nitrite, and histamine all reduced the lethal dose of procaine sufficient to cause paralysis of the respiratory center.

3. The probability of a relationship between anoxia and this reduction of the lethal dose of procaine is pointed out.

Submitted on June 4, 1933






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Copyright © 1934 by the American Society for Pharmacology and Experimental Therapeutics.