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Journal of Pharmacology And Experimental Therapeutics, Vol. 49, Issue 4, 375-386, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

THE SECRETION OF THE POSTERIOR LOBE OF THE HYPOPHYSIS AFTER THE ADMINISTRATION OF DRUGS

ALEXANDER SIMON 1

1 Department of Pharmacology and Experimental Therapeutics, Johns Hopkins School of Medicine, Baltimore, Maryland

1. An attempt has been made to determine the vasopressin content of cerebrospinal fluids taken before and after insulin administration from unanesthetized dogs, using the sensitive ileum of the guinea pig as test object. No appreciable amount was detected.

2. Insulin, urea, and novasurol administration failed to increase the oxytocic effect of the cerebrospinal fluids of dogs.

3. The behavior of the isolated guinea pig ileum toward different doses of vasopressin and in different bath fluids is described.

Submitted on March 20, 1933






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