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Journal of Pharmacology And Experimental Therapeutics, Vol. 49, Issue 3, 306-318, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

MYOCARDITIS PRODUCED EXPERIMENTALLY IN RABBITS BY DRUGS

CHARLES M. GRUBER 1, ISAAC Y. OLCH 1, and BRIAN BLADES 1

1 From the Departments of Pharmacology and Surgery, Washington University, School of Medicine, St. Louis, Missouri, and the Department of Pharmacology, Jefferson Medical College, Philadelphia

Myocard tis can be produced in rabbits upon the administration of any of the methyl xanthin group of drugs when they are followed within two minutes by the administration of epinephrine in proper dosages. Similar cardiac changes can be produced in a fair percentage of cases upon the administration of the xanthin derivatives followed by an injection of either ephedrine sulphate or tyramine acid phosphate.

Submitted on February 15, 1933






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Copyright © 1933 by the American Society for Pharmacology and Experimental Therapeutics.