FURTHER STUDIES CONCERNING THE ACTION OF DIURETICS UPON THE AGLOMERULAR KIDNEY

¹ From the Department of Pharmacology, The University of Minnesota Medical School, Minneapolis

Equimolecular solutions of chlorides of a series of cations have been studied in the aglomerular kidney relative to their ability to increase the volume flow of urine (diuresis).

The chlorides of Li⁺, Na⁺, K⁺ and Rb⁺ produce a progressively increasing diuresis with increase of molecular weight.

The chlorides of Mg⁺⁺, Ca⁺⁺ Sr⁺⁺ and Hg⁺⁺ produce a progressively decreasing diuresis with increase of molecular weight.

Li⁺, and Na⁺ have practically no effect upon the urine flow from the aglomerular kidney.

Mg⁺⁺ has the most marked diuretic effect upon the aglomerular kidney.

NaI and KBr produce results entirely identical with the corresponding chlorides.

Sodium thiosulphate, ammonium chloride and Creatinine are also diuretic for the aglomerular kidney.

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