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Journal of Pharmacology And Experimental Therapeutics, Vol. 49, Issue 2, 209-214, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF COCAINE ON THE INTESTINE

FREDERICK BERNHEIM 1

1 From the Department of Physiology and Pharmacology, Duke University School of Medicine, Durham, North Carolina

1. Cocaine in concentrations of 0.1 to 0.2 per cent causes relaxation of the guinea pig ileum contracted by histamin or pilocarpine. The extent of the relaxation is a function of the amount of cocaine added and the amount of histamin or pilocarpine.

2. Cocaine causes relaxation of the ileum after contraction by barium.

3. The action of nicotine and cocaine is additive.

4. It is concluded that cocaine like nicotine and atropine acts both on smooth muscle directly and on the parasympathetic endings.

Submitted on January 16, 1933






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Copyright © 1933 by the American Society for Pharmacology and Experimental Therapeutics.