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Journal of Pharmacology And Experimental Therapeutics, Vol. 48, Issue 3, 371-374, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

THE LOCAL ANESTHETIC ACTION OF p-AMINOBENZOATES OF DIETHYLAMINO-ETHOXY ALCOHOLS

W. H. HORNE 1 and R. L. SHRINER 1

1 From the Chemical Laboratory of the University of Illinois, Urbana, Illinois

The local anesthetic action of compounds of the general formula

[See formula in the PDF file]

has been studied. It was found that where n = 1 the compound has low toxicity and high anesthetizing power. The introduction of the ether linkage in the side chain enables the molecule to cause surface anesthesia as well as injection anesthesia. The higher homologues (n = 2, 3, 4) are too irritating for use.

Submitted on December 5, 1932






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Copyright © 1933 by the American Society for Pharmacology and Experimental Therapeutics.