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Journal of Pharmacology And Experimental Therapeutics, Vol. 48, Issue 2, 229-233, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF DIFFERENT NARCOTICS AND NARCOTIC COMBINATIONS ON THE MINIMUM LETHAL DOSE OF PROCAINE HYDROCHLORIDE INTRACISTERNALLY

FRANK WANG COTUI 1

1 From the Laboratory of Surgical Research, New York University and Bellevue Medical College, New York City

Summarizing the different narcotics administered singly and in combination:

1. Morphine in small effective doses, that is, doses which produce a clear cut depression, causes no appreciable reduction in the lethal dose of procaine intracisternally; in larger doses, however, a reduction seems to take place.

2. Morphine-scopolamine causes no appreciable reduction.

3. Sodium amytal causes a marked reduction.

4. Avertin with a small dose of morphine causes no perceptible reduction, while with larger doses of morphine a reduction seems to take place.

Submitted on October 17, 1932






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Copyright © 1933 by the American Society for Pharmacology and Experimental Therapeutics.