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Journal of Pharmacology And Experimental Therapeutics, Vol. 48, Issue 1, 89-94, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF THE SEPARATED FRACTIONS OF THE POSTERIOR LOBE OF THE PITUITARY ON THE FAT CONTENT OF THE LIVER

A. C. WHITE 1

1 The Wellcome Physiological Research Laboratories, Beckenham, Kent

The oxytocic substance of the posterior pituitary hormone produces no naked eye or microscopic changes in the livers of normal rabbits which are not found in the livers of control rabbits; whereas the fraction containing a marked excess of pressor activity and also melanophore activity causes fatty infiltration in varying degree. These changes are reflected in the amount of ethersoluble material extracted from the liver. The pressor fraction causes a very great increase, the oxytocic fraction much less. The pressor fraction therefore is probably mainly responsible for the changes observed by Coope and Chamberlain (1).

Submitted on July 31, 1932






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