JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 48, Issue 1, 73-78, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF VERATRINE AND URETHANE ON TISSUE OXIDATIONS

FREDERICK BERNHEIM 1 and MARY L. C. BERNHEIM 1

1 From the Departments of Physiology and Biochemistry, Duke University School of Medicine, Durham, North Carolina

1. Veratrine inhibits the oxygen uptake of mammalian muscle, kidney, and liver. It is between 100 to 150 times more toxic than urethane. It has no effect on the respiratory quotient.

2. Veratrine has no effect on the oxidation of lactic and succinic acids, accelerates the oxidation of tyramine and completely inhibits the oxidation of proline and xanthine by liver.

3. Both veratrine and urethane in small concetrations accelerate the oxygen uptake of yeast whereas in large concentrations they inhibit.

Submitted on July 29, 1932






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