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Journal of Pharmacology And Experimental Therapeutics, Vol. 48, Issue 1, 25-49, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF THE EFFECTS OF AGAVE CONCENTRATE IN THE TREATMENT OF EXPERIMENTAL NEPHRITIS INDUCED IN ANIMALS II. NEPHRITIS INDUCED IN DOGS BY THE USE OF URANIUM NITRATE

HERMAN D. JONES 1, R. C. HUGHES 1, and G. BERNARD JOHNSTON 1

1 From the Laboratory of Biological Chemistry, Department of Chemistry, Alabama Polytechnic Institute, Auburn, Alabama

1. A uniformly acute uranium nephritis was produced.

2. Seven of the 10 control animals of group I died, giving a 70 per cent mortality.

3. Five of the 16 animals which received both the uranium nitrate and the agave concentrate in group I died, giving a 31 per cent mortality.

4. The functional changes of all control animals and the kidney pathology are in close agreement with those of MacNider (6).

5. The functional changes and the pathology of those animals receiving both the uranium nitrate and the agave concentrate showed a marked improvement over those of the control animals.

6. There was not a sufficient renal disturbance developed in animals of group II for the results to be significant.

From these observations the agave concentrate apparently had a protective action on the kidney or aided materially in eliminating the uranium nitrate in a very short time, thus preventing its corrosive action on that organ.

Submitted on July 23, 1932






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Copyright © 1933 by the American Society for Pharmacology and Experimental Therapeutics.