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Journal of Pharmacology And Experimental Therapeutics, Vol. 47, Issue 3, 355-363, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF PITUITARY EXTRACT UPON THE BLOOD PRESSURE OF THE NORMAL UNANESTHETIZED ANIMAL AND THE EFFECTS OF EPHEDRINE OR ADRENALINE THEREUPON

K. I. MELVILLE 1

1 Department of Pharmacology, McGill University, Montreal, Canada

Experiments are described which show that the fall in blood pressure which follows the intravenous injection of pituitary extract in the normal unanesthetized dog may be diminished or abolished by the administration of adrenaline or ephedrine.

It is suggested that the fall in pressure is due to coronary constriction, and its elimination by means of adrenaline or ephedrine is the result of the coronary dilatation produced by these substances.

Submitted on July 18, 1932






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Copyright © 1933 by the American Society for Pharmacology and Experimental Therapeutics.