JPET Celsis microsomes equal better data

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by D'AMOUR, M. C.
Right arrow Articles by VAN DYKE, H. B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by D'AMOUR, M. C.
Right arrow Articles by VAN DYKE, H. B.
Journal of Pharmacology And Experimental Therapeutics, Vol. 47, Issue 3, 269-280, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

THE INHIBITION OF OESTRUS BY EXTRACTS OF THE ANTERIOR LOBE OF THE PITUITARY BODY

MARIE C. D'AMOUR 1 and H. B. VAN DYKE 1

1 From the Pharmacological Laboratory, the University of Chicago, Illinois

1. Extracts capable of causing the inhibition of oestrus in the adult female white rat were prepared from both beef anterior lobes and from sheep whole pituitary bodies. It was found best to carry out extraction at an alkaline pH. Glands which had been desiccated by acetone and subsequently powdered were found to be satisfactory.

2. Extracts of sheep whole pituitary body (compared with those of beef anterior lobe) were consistently found to be more potent both in stimulating the ovary of the immature rat and in inhibiting oestrus in the adult rat.

3. Extracts of nine control tissues caused no lengthening of the oestrous cycle. The characteristic ovarian changes found in the animals receiving anterior pituitary extracts were not observed in the ovaries of animals receiving extracts of other tissues.

4. The assay of extracts causing the inhibition of oestrus is discussed.

Submitted on July 11, 1932






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1933 by the American Society for Pharmacology and Experimental Therapeutics.