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Journal of Pharmacology And Experimental Therapeutics, Vol. 47, Issue 1, 47-68, 1933
Copyright © 1933 by American Society for Pharmacology and Experimental Therapeutics

TRIBROMETHANOL (AVERTIN) NARCOSIS IN THE TREATMENT OF LUNG EDEMA INDUCED BY CHEMICAL IRRITATION

AMOS R. KOONTZ 1 and CARL H. MOULTON 1

1 From the Medical Research Division, Chemical Warfare Service, Edgewood Arsenal, Edgewood, Maryland

Various doses of calcium chloride and calcium lactate (given orally by stomach tube) were used in the treatment of the edema of the lungs caused by gassing with phosgene, both in rabbits and in dogs. A considerable decrease in the edema was secured by this therapy, but no reduction in the percentage dying was effected.

The use of avertin (100 mgm. per kilogram of body weight) was then tried as a method of treatment in dogs. The narcosis produced kept the animals quiet for a number of hours after gassing. Occasionally the dose was repeated twenty-four hours later. The method effected a marked reduction in the amount of edema of the lungs, and reduced the percentage of deaths by half.

Submitted on April 27, 1932






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