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Journal of Pharmacology And Experimental Therapeutics, Vol. 46, Issue 2, 229-250, 1932
Copyright © 1932 by American Society for Pharmacology and Experimental Therapeutics

ON THE BIOLOGICAL ASSAY OF DIGITALIS AND STROPHANTHTJS

C. W. CHAPMAN 1 and C. A. MORRELL 1

1 Laboratory of Hygiene, Department of Pensions and National Health, Ottawa, Canada

1. A frog method for the biological assay of digitalis and strophanthus preparations is described in detail.

2. The method eliminates the effect of individual variation in the frogs and variations which occur from time to time.

3. The results of a series of assays on tinctures of digitalis and strophanthus are presented.

4. The official U. S. P. X method is discussed in comparison with the method described. The wide fluctuations in the M. S. D. values for ouabain are attributed to neglect of the effect of individual differences in the sensitivity of the frogs.

5. Seasonal, diurnal and species variations are discussed.

6. It is maintained that the frog method, using the technique described, combines accuracy, simplicity and economy to a greater degree than other methods.

Submitted on March 14, 1932




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 Arch Intern MedHome page
M. A. SCHNITKER and S. A. LEVINE
PRESENCE OF DIGITALIS IN BODY FLUIDS OF DIGITALIZED PATIENTS
Arch Intern Med, August 1, 1937; 60(2): 240 - 250.
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Copyright © 1932 by the American Society for Pharmacology and Experimental Therapeutics.