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Journal of Pharmacology And Experimental Therapeutics, Vol. 46, Issue 1, 125-129, 1932
Copyright © 1932 by American Society for Pharmacology and Experimental Therapeutics

THE USE OF SODIUM AMYTAL IN THE PRODUCTION OF ANESTHESIA IN THE RAT

J. S. NICHOLAS 1 and D. H. BARRON 1

1 Osborn Zoological Laboratory Yale University

1. Sodium amytal (Lilly) affords a safe and convenient method for the routine production of anesthesia in the rat.

2. There is a marked difference in the amount of the substance which can be safely employed in males and females. The female dosage is just one-half the male dosage. Immature rats require the lower dosage.

3. The efficiency of the drug is lessened by dilution. The more concentrated solutions produce more uniform results with the actual use of less amytal.

4. In the rat, the only contraindication to the use of sodium amytal so far found is a chronic respiratory infection.

5. Death in cases of overdosage is generally due to respiratory failure.

Submitted on January 25, 1932




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Copyright © 1932 by the American Society for Pharmacology and Experimental Therapeutics.