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Journal of Pharmacology And Experimental Therapeutics, Vol. 45, Issue 3, 291-298, 1932
Copyright © 1932 by American Society for Pharmacology and Experimental Therapeutics

SPINAL ANESTHESIA IN SUMMER FROGS

RAYMOND N. BIETER 1, A. McG. HARVEY 1, and W. W. BURGESS 1

1 From the Department of Pharmacology, The University of Minnesota Medical School, Minneapolis

A simple technique for producing spinal anesthesia in the frog is described. This method is suitable for class experimentation and for obtaining relative evidence on the value of spinal anesthetics.

A series of local anesthetics has been studied by this method in summer frogs. The therapeutic coefficient of each has been determined by the fraction M.L.D./M.A.D. In order, beginning with the anesthetic of lowest therapeutic coefficient, these drugs are: nupercaine, stovaine, butyn, alypine, pantocaine, procaine, neothesine, cocaine, and tutocaine.

Submitted on December 9, 1931






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Copyright © 1932 by the American Society for Pharmacology and Experimental Therapeutics.