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Journal of Pharmacology And Experimental Therapeutics, Vol. 44, Issue 4, 449-455, 1932
Copyright © 1932 by American Society for Pharmacology and Experimental Therapeutics

FURTHER STUDIES OF THE CONTROL OF EXPERIMENTALLY PRODUCED CONVULSIONS

HADDOW M. KEITH 1

1 Section on Pediatrics, The Mayo Clinic, Rochester, Minnesota

In rabbits the anticonvulsive effect of diacetone alcohol given by mouth is definite. A considerably larger amount of it is required than is required of phenobarbital to produce a similar effect. The latter, however, is much more toxic in larger doses, and causes considerably more irritability to sensory stimuli. The anticonvulsive properties of diacetone alcohol depend on the acetone portion of the molecule. beta-hydroxybutyric acid, in itself, is not anticonvulsive.

Submitted on October 10, 1931




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T. J. Putnam and H. H. Merritt
EXPERIMENTAL DETERMINATION OF THE ANTICONVULSANT PROPERTIES OF SOME PHENYL DERIVATIVES
Science, May 28, 1937; 85(2213): 525 - 526.
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Copyright © 1932 by the American Society for Pharmacology and Experimental Therapeutics.