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Journal of Pharmacology And Experimental Therapeutics, Vol. 44, Issue 2, 253-267, 1932
Copyright © 1932 by American Society for Pharmacology and Experimental Therapeutics

CLAUDE BERNARD'S THEORY OF NARCOSIS

V. E. HENDERSON 1 and G. H. W. LUCAS 1

1 Department of Pharmacology, University of Toronto

1. Experiments designed to show a specific antagonism between sodium thiocyanate and several narcotic agents have failed entirely to support the claims made by Bancroft and Reitzler that a marked decrease in anaesthesia and a marked increase in respiration is produced by the administration of sodium thiocyanate.

2. A discussion of Bancroft's statement of the Claude Bernard theory of narcosis shows that Bancroft has not been able to demonstrate that coagulation (as the term is usually understood) always accompanies narcosis. This and other evidence which is so ably presented by Winterstein (22) (p. 357-60), and discussed more briefly by Henderson (15), leads us to reject a coagulation theory of narcosis. And this is true, even if we use the word "coagulation" with the Bancroft connotation.






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Copyright © 1932 by the American Society for Pharmacology and Experimental Therapeutics.