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Journal of Pharmacology And Experimental Therapeutics, Vol. 43, Issue 4, 697-708, 1931
Copyright © 1931 by American Society for Pharmacology and Experimental Therapeutics

THE TOLERANCE OF THE TOAD TOWARDS STROPHANTHIN

DAVID EPSTEIN 1

1 From the Department of Pharmacology, University of Cape Town

1. The toad Bufo regularis is about 1000 times more tolerant to strophanthin than the frog Xenopus laevis.

2. The same degree of tolerance is shown by the perfused heart of the toad, so that the tolerance of the toad to strophanthin can be completely explained as due to the tolerance of its heart.

3. Strophanthin is able to produce systolic standstill of the heart of the toad, as in the case of the frog.

4. Strophanthin exerts a direct stimulant effect on the spinal cord of the toad resulting in strychnine-like convulsions. This may later be followed by complete paralysis of the nervous system.

5. A possible error that may occur when drugs are injected into the ventral lymph sacs has been referred to, and the use of alternative sites of injection has been suggested.

Submitted on July 22, 1931






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Copyright © 1931 by the American Society for Pharmacology and Experimental Therapeutics.