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Journal of Pharmacology And Experimental Therapeutics, Vol. 43, Issue 1, 51-60, 1931
Copyright © 1931 by American Society for Pharmacology and Experimental Therapeutics

THE RELATION OF ACQUIRED MORPHINE TOLERANCE TO THE ADRENAL CORTEX

EATON M. MACKAY 1

1 From the Department of Medicine, Stanford University Medical School, San Francisco and the The Scripps Metabolic Clinic, La Jolla, California

The administration of morphine to the albino rat results in hypertrophy of the adrenal gland due in large part if not entirely to an increase in the volume of the cortex.

There is a definite relation between the dose of morphine attained and the increase in morphine tolerance on the one hand and the hypertrophy of the adrenal cortex on the other. It is pointed out that these factors may not be dependent on one another.

Submitted on April 2, 1931






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Copyright © 1931 by the American Society for Pharmacology and Experimental Therapeutics.